Filatova N A, Kuznetsov E A, Dmitrieva L A, Tsarev V N, Kalinin A I
Stomatologiia (Mosk). 1995;74(1):12-5.
Antibacterial activity of sumamed, a macrolide antibiotic, in respect of anaerobic microflora of the oral cavity, such as Bacteroides, Prevotella, Porphyromonas, Fusobacterium, Peptostreptococcus, Str. sanguis and Staph. aureus, was assessed. The drug was found to be highly effective in respect of bacteroids (MPC90: 1,4 to 30 mg/mlMg/ml, this permitting the use of sumamed in the treatment of 9 patients with chronic generalized periodontitis in the exacerbation stage. Bacteriological and clinical control of the results of therapy demonstrated the drug efficacy in respect of periodontopathogenous flora, particularly as regards bacteroids and fusobacteria which maintain the inflammatory process in periodontitis.
对一种大环内酯类抗生素舒美特（Sumamed）针对口腔厌氧微生物群（如拟杆菌属、普雷沃菌属、卟啉单胞菌属、梭杆菌属、消化链球菌属、血链球菌和金黄色葡萄球菌）的抗菌活性进行了评估。发现该药物对拟杆菌非常有效（MPC90：1.4至30毫克/毫升，这使得舒美特可用于治疗9例处于急性加重期的慢性广泛性牙周炎患者。对治疗结果的细菌学和临床对照证明了该药物对牙周病原性菌群有效，特别是对于在牙周炎中维持炎症过程的拟杆菌和梭杆菌。
