急性未成熟型髓细胞白血病的异质性：一项超微结构研究。

Heterogeneity of acute myeloblastic leukemia without maturation: an ultrastructural study.

作者信息

Hamamoto K, Date M, Taniguchi H, Nagano T, Kishimoto Y, Kimura T, Fukuhara S

机构信息

First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.

出版信息

Ultrastruct Pathol. 1995 Jan-Feb;19(1):9-14. doi: 10.3109/01913129509014598.

DOI:10.3109/01913129509014598

PMID:7770965

Abstract

We demonstrated by ultrastructural examination that the leukemic blasts of 13 patients with acute myeloblastic leukemia (AML) without maturation (M1 in the French-American-British classification) showed heterogeneous features. In 7 patients, the leukemic blasts had a high level of light microscopic myeloperoxidase positivity (> 50%). Ultrastructurally, the cells were myeloblast-promyelocytes with 100% myeloperoxidase positivity, and these 7 patients appeared to have typical AML. In contrast, the remaining 6 patients had leukemic blasts with a low myeloperoxidase positivity (< 50%) and heterogeneous features. Three had ultrastructural features of myelomonocytic or monocytic lineage, 1 had myelomonocytic cells associated with megakaryoblasts, and 1 had undifferentiated blasts. The former group had a better prognosis than the latter, indicating that ultrastructural analysis of M1 leukemia may help predict the response to therapy.

摘要

我们通过超微结构检查证明，13例急性髓细胞白血病（AML）未成熟型（法国-美国-英国分类法中的M1）患者的白血病原始细胞表现出异质性特征。7例患者的白血病原始细胞光镜下髓过氧化物酶阳性水平较高（>50%）。超微结构上，这些细胞为原始粒细胞-早幼粒细胞，髓过氧化物酶阳性率为100%，这7例患者似乎患有典型的AML。相比之下，其余6例患者的白血病原始细胞髓过氧化物酶阳性率较低（<50%）且具有异质性特征。3例具有髓单核细胞或单核细胞系的超微结构特征，1例有与原始巨核细胞相关的髓单核细胞，1例有未分化的原始细胞。前一组的预后比后一组好，这表明对M1白血病进行超微结构分析可能有助于预测治疗反应。