Burnett A L
Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Urology. 1995 Jun;45(6):1071-83. doi: 10.1016/s0090-4295(99)80136-8.
It is apparent that evolving concepts of the regulatory basis for functions in the pelvis must take into account the role exerted by nitric oxide. A recently characterized messenger molecule, nitric oxide has been associated with numerous physiologic processes. Intense investigations of this molecule have extended its importance to several genitourinary functions. Penile erection, micturition, peristalsis of the male excurrent duct system, contractile properties of the prostate, and lumbosacral spinal cord neurotransmission are all functions that may transpire under some degree of control by nitric oxide. Impotence, urinary obstruction, or ejaculatory problems, in turn, may represent alterations of nitric oxide production or action. The strategic manipulation of nitric oxide or its mechanism of action, possibly by pharmacologic means, may restore or produce desired functional effects. These possibilities, therefore, suggest that the advancing knowledge of nitric oxide in the genitourinary tract may be of enormous clinical value in the future.
显然，不断发展的骨盆功能调节基础概念必须考虑一氧化氮所发挥的作用。一氧化氮是一种最近被鉴定出的信使分子，它与众多生理过程相关。对该分子的深入研究已将其重要性扩展到多个泌尿生殖功能方面。阴茎勃起、排尿、男性排精管道系统的蠕动、前列腺的收缩特性以及腰骶部脊髓神经传递，都是在一定程度上可能受一氧化氮控制的功能。反过来，阳痿、尿路梗阻或射精问题可能代表一氧化氮产生或作用的改变。通过药理学手段对一氧化氮或其作用机制进行策略性调控，可能恢复或产生预期的功能效果。因此，这些可能性表明，未来关于一氧化氮在泌尿生殖道方面的知识进展可能具有巨大的临床价值。
