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P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer.

作者信息

Nedelcheva V, Gut I

机构信息

National Institute of Public Health, Department of Occupational Medicine, Praha, Czech Republic.

出版信息

Xenobiotica. 1994 Dec;24(12):1151-75. doi: 10.3109/00498259409038673.

DOI:10.3109/00498259409038673
PMID:7771104
Abstract
  1. Considerable evidence has been accumulated that orthologous rat and human P450 forms oxidize numerous chemicals in a highly similar manner, including the detoxication and activation of mutagens and carcinogens. 2. Nevertheless, certain specific substrates of rat P450s are not so well oxidized by the orthologous human forms, and vice versa. 3. Certain mutagens and carcinogens can be activated in a similar way by different (non-orthologous) forms in rat and man, confirming that studies on animals, directed ultimately to man, can be indicative but not predicative of chemical mutagenesis and carcinogenesis.
摘要

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