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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Zhang A Q, Mitchell S C, Smith R L

Department of Pharmacology and Toxicology, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.

Xenobiotica. 1994 Dec;24(12):1215-21. doi: 10.3109/00498259409038677.

[U-14C]-dimethylamine hydrochloride was administered by gavage (20 mumol/kg body weight) to adult male Wistar rat and CD1 strain mouse. 2. In both species, urine was the main route of excretion with the majority of radiolabel (91%) being voided during the first day. Additional small amounts of radioactivity were detected in the 24-72 h urine (2%), in faeces (2%) and amidst exhaled air (1%), with minor amounts remaining within the carcass (1%) after 3 days. 3. Metabolism was limited to demethylation, with the majority of the compound (89% dose; 96% urinary radioactivity) being excreted unchanged.

将[U-14C]-二甲胺盐酸盐通过灌胃法给予成年雄性Wistar大鼠和CD1品系小鼠（20微摩尔/千克体重）。2. 在这两个物种中，尿液是主要排泄途径，大部分放射性标记物（91%）在第一天排出。在24 - 72小时的尿液中检测到少量额外放射性（2%），粪便中（2%）以及呼出气体中（1%），3天后尸体中残留少量（1%）。3. 代谢仅限于去甲基化，大部分化合物（89%剂量；96%尿放射性）以原形排泄。

Zhang A Q, Mitchell S C, Smith R L

Department of Pharmacology and Toxicology, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.

Xenobiotica. 1994 Dec;24(12):1215-21. doi: 10.3109/00498259409038677.

[U-14C]-dimethylamine hydrochloride was administered by gavage (20 mumol/kg body weight) to adult male Wistar rat and CD1 strain mouse. 2. In both species, urine was the main route of excretion with the majority of radiolabel (91%) being voided during the first day. Additional small amounts of radioactivity were detected in the 24-72 h urine (2%), in faeces (2%) and amidst exhaled air (1%), with minor amounts remaining within the carcass (1%) after 3 days. 3. Metabolism was limited to demethylation, with the majority of the compound (89% dose; 96% urinary radioactivity) being excreted unchanged.

将[U-14C]-二甲胺盐酸盐通过灌胃法给予成年雄性Wistar大鼠和CD1品系小鼠（20微摩尔/千克体重）。2. 在这两个物种中，尿液是主要排泄途径，大部分放射性标记物（91%）在第一天排出。在24 - 72小时的尿液中检测到少量额外放射性（2%），粪便中（2%）以及呼出气体中（1%），3天后尸体中残留少量（1%）。3. 代谢仅限于去甲基化，大部分化合物（89%剂量；96%尿放射性）以原形排泄。