Meller W H, Kathol R G, Samuelson S D, Gehris T L, Carroll B T, Pitts A F, Clayton P J
Department of Psychiatry, University of Minnesota, Minneapolis, USA.
Biol Psychiatry. 1995 Mar 15;37(6):376-82. doi: 10.1016/0006-3223(94)00132-M.
Recently, renewed interest has developed in the concept of anxious depression. Using an operational definition of "anxious depression" based on the SADS interview, 25 patients with major depressive disorder were separated into anxious (n = 14) and nonanxious (n = 11) subtypes. These two patient groups and normal control subjects received an intravenous corticotropin-releasing hormone challenge test. Adrenocorticotropic hormone (ACTH) and cortisol responses were compared among the three groups. Patients with anxious depression had significant attenuation of ACTH response when compared to nonanxious patients and normal control subjects.
最近，人们对焦虑性抑郁的概念重新产生了兴趣。根据情感障碍和精神分裂症日程表访谈制定了“焦虑性抑郁”的操作性定义，将25名重度抑郁症患者分为焦虑型（n = 14）和非焦虑型（n = 11）亚型。这两组患者以及正常对照受试者接受了静脉注射促肾上腺皮质激素释放激素激发试验。比较了三组之间促肾上腺皮质激素（ACTH）和皮质醇的反应。与非焦虑型患者和正常对照受试者相比，焦虑性抑郁患者的ACTH反应明显减弱。
