van Ginkel C J, Sabapathy N N
Department of Dermatology, University Hospital Utrecht, The Netherlands.
Contact Dermatitis. 1995 Mar;32(3):160-2. doi: 10.1111/j.1600-0536.1995.tb00807.x.
In spring 1992, several farmers in the western part of The Netherlands developed dermatitis on their hands, forearms and face. In some, the legs, trunk and genitals were also affected. Complaints ranged from a mildly itchy, papular rash to a painful, weeping and blistering dermatitis. Medical aid was needed by 5/9 of them. Some of the farmers grew seed potatoes, the others cultivated lilies. All of them had in common that their complaints emerged after repeated application of a new fungicide over several weeks. The fungicide was Shirlan, with fluazinam as its active ingredient. 9 farmers were patch tested with a concentration range of the whole formulation (aq.) and of the active ingredient (pet.). In 7 of 9 farmers, positive patch tests were scored with both the whole formulation (down to 0.01% aq.) and fluazinam itself (down to 0.1% pet.). Patch tests in consecutive control patients (n = 10) were all negative. As it was impossible to substitute fluazinam as the active ingredient, farmers are now supplied with detailed information as to how to avoid skin contact as much as feasible.
1992年春，荷兰西部的几位农民手部、前臂和面部出现皮炎。部分患者的腿部、躯干和生殖器也受到影响。症状从轻微瘙痒的丘疹性皮疹到疼痛、渗出和水疱性皮炎不等。其中九分之五的患者需要医疗救助。一些农民种植种用马铃薯，另一些种植百合。他们的共同之处在于，在数周内反复施用一种新型杀菌剂后出现了症状。这种杀菌剂是适乐时，其活性成分是氟啶胺。对9名农民进行了该制剂全配方（水溶液）和活性成分（凡士林）不同浓度范围的斑贴试验。9名农民中有7名对全配方（低至0.01%水溶液）和氟啶胺本身（低至0.1%凡士林）的斑贴试验呈阳性。连续10名对照患者的斑贴试验均为阴性。由于无法替换氟啶胺这种活性成分，现在已向农民提供了详细信息，告知他们如何尽可能避免皮肤接触。
