Willens H J, Chakko S C, Kessler K M
Department of Medicine, University of Miami School of Medicine, Fla., USA.
Chest. 1994 Aug;106(2):594-600. doi: 10.1378/chest.106.2.594.
The medical complications of cocaine abuse are being encountered by clinicians with increasing frequency. The cardiovascular manifestations of cocaine abuse include chest pain, myocardial ischemia and infarction, congestive heart failure, arrhythmias, infective endocarditis, and aortic dissection. The pathogenesis of these cardiovascular complications has not been fully elucidated but may be related to a combination of the sympathomimetic and membrane anaesthetic effects of cocaine. We present these concepts in a case discussion format.
临床医生越来越频繁地遇到可卡因滥用导致的医学并发症。可卡因滥用的心血管表现包括胸痛、心肌缺血和梗死、充血性心力衰竭、心律失常、感染性心内膜炎以及主动脉夹层。这些心血管并发症的发病机制尚未完全阐明,但可能与可卡因的拟交感神经作用和膜麻醉作用的综合影响有关。我们以病例讨论的形式呈现这些概念。