Chen G D, Jastreboff P J
Department of Surgery, University of Maryland School of Medicine, Baltimore 21201, USA.
Hear Res. 1995 Feb;82(2):158-78. doi: 10.1016/0378-5955(94)00174-o.
The evaluation of the spontaneous activity of 471 units from the external nucleus of the IC revealed that salicylate induces an increase of the spontaneous activity and the emergence of a bursting type of activity longer than 4 spikes. For sharply tuned units, the affected cells were from the frequency range of 10-16 kHz, which corresponds to the behaviorally measured pitch of salicylate-induced tinnitus in rats. An exogenous calcium supplement, provided under the conditions shown to attenuate the behavioral manifestation of salicylate-induced tinnitus, abolished the modification of the spontaneous activity induced by salicylate. Finally, profound changes of activity were observed for cells not responding to contralateral sound. We propose that the observed long bursts of discharges represent tinnitus-related neuronal activity. The results are consistent with the hypothesis that GABA-mediated disinhibition is involved in the processing of tinnitus-related neuronal activity.
对下丘外侧核471个神经元自发活动的评估显示，水杨酸盐可诱导自发活动增加，并出现持续时间超过4个峰电位的爆发式活动。对于调谐敏锐的神经元，受影响的细胞频率范围为10 - 16千赫兹，这与行为学测量的大鼠水杨酸盐诱导耳鸣的音调相对应。在已证明可减弱水杨酸盐诱导耳鸣行为表现的条件下提供外源性钙补充剂，可消除水杨酸盐诱导的自发活动改变。最后，观察到对侧声音无反应的细胞活动发生了显著变化。我们认为观察到的长时间放电爆发代表与耳鸣相关的神经元活动。这些结果与GABA介导的去抑制参与与耳鸣相关神经元活动处理的假说一致。
