水杨酸钠通过增加刺激呈现率改变时间整合的测量。
Sodium salicylate alters temporal integration measured through increasing stimulus presentation rates.
机构信息
a Department of Biology , University of South Florida , Tampa , FL , USA.
b Morsani College of Medicine , University of South Florida , Tampa , FL , USA.
出版信息
Int J Audiol. 2019 Mar;58(3):141-150. doi: 10.1080/14992027.2018.1544424.
OBJECTIVE
High doses of sodium salicylate (SS) are known to induce tinnitus, general hyperexcitability in the central auditory system, and to cause mild hearing loss. We used the auditory brainstem response (ABR) to assess the effects of SS on auditory sensitivity and temporal processing in the auditory nerve and brainstem. ABRs were evoked using tone burst stimuli varying in frequency and intensity with presentation rates from 11/s to 81/s.
DESIGN
ABRs were recorded and analysed prior to and after SS treatment in each animal, and peak 1 and peak 4 amplitudes and latencies were determined along with minimal response threshold.
STUDY SAMPLE
Nine young adult CBA/CaJ mice were used in a longitudinal within-subject design.
RESULTS
No measurable effects of presentation rate were found on ABR threshold prior to SS; however, following SS administration increasing stimulus rates lowered ABR thresholds by as much as 10 dB and compressed the peak amplitude by intensity level functions.
CONCLUSIONS
These results suggest that SS alters temporal integration and compressive nonlinearity, and that varying the stimulus rate of the ABR may prove to be a useful diagnostic tool in the study of hearing disorders that involve hyperexcitability.
目的
高剂量的水杨酸钠（SS）已知可引起耳鸣、中枢听觉系统普遍过度兴奋，并导致轻度听力损失。我们使用听觉脑干反应（ABR）来评估 SS 对听觉神经和脑干听觉敏感性和时间处理的影响。使用不同频率和强度的短音刺激来诱发 ABR，呈现率从 11/s 到 81/s。
设计
在每个动物的 SS 处理前后记录和分析 ABR，并确定峰 1 和峰 4 的幅度和潜伏期，以及最小反应阈值。
研究样本
9 只年轻成年 CBA/CaJ 小鼠用于纵向自身对照设计。
结果
在 SS 之前，ABR 阈值没有发现呈现率的可测量影响；然而，在 SS 给药后，增加刺激率可使 ABR 阈值降低多达 10dB，并通过强度水平函数压缩峰幅度。
结论
这些结果表明，SS 改变了时间整合和压缩非线性，并且改变 ABR 的刺激率可能成为研究涉及过度兴奋的听力障碍的有用诊断工具。
Zotero 插件