人成纤维细胞热处理后，转录活性基因中紫外线诱导的嘧啶（6-4）嘧啶酮光产物的修复被选择性抑制。

Repair of UV-induced pyrimidine(6-4)pyrimidone photoproducts is selectively inhibited in transcriptionally active genes after heat treatment of human fibroblasts.

作者信息

Sakkers R J, Filon A R, Kampinga H H, Konings A W, Mullenders L H

机构信息

MGC-Department of Radiation Genetics and Chemical Mutagenesis, Leiden University, The Netherlands.

出版信息

Int J Radiat Biol. 1995 May;67(5):495-9. doi: 10.1080/09553009514550601.

DOI:10.1080/09553009514550601

Abstract

In normal human fibroblasts, repair of (6-4)PP in the active adenosine deaminase (ADA) gene occurs with similar rate in the transcribed and non-transcribed strand of the ADA gene, and removal of (6-4)PP from the active ADA gene is faster than from the inactive X-chromosomal 754 locus. Heat shock decreased the rate of repair of the active ADA gene down to the level of inactive genes, whereas the rate of repair of the inactive 754 locus was not affected.

摘要

在正常人类成纤维细胞中，活性腺苷脱氨酶（ADA）基因中（6-4）光产物的修复在ADA基因的转录链和非转录链中以相似的速率发生，并且从活性ADA基因中去除（6-4）光产物的速度比从无活性的X染色体754位点更快。热休克将活性ADA基因的修复速率降低至无活性基因的水平，而无活性754位点的修复速率不受影响。

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