Caplan R H, Wickus G G, Sloane K, Silva P D
Department of Laboratory Medicine, Gundersen/Lutheran Medical Center, La Crosse, Wisconsin, USA.
J Reprod Med. 1995 Mar;40(3):216-8.
We measured parathyroid hormone-related protein (PTHrP) in the serum of 15 healthy women within three days of beginning breast-feeding and within one hour of completing nursing. A sensitive immunoradiometric assay that measures N-terminal PTHrP containing at least the first 74 amino acids was used. We found normal PTHrP values in all patients. Values one day before and two days after delivery in a hypoparathyroid woman who chose not to breast-feed were also normal. Since N-terminal PTHrP fragments of 1-36 amino acids or more are biologically active, we believe additional studies using sensitive PTHrP assays that measure smaller fragments and investigations performed under other conditions of breast-feeding are necessary before concluding that PTHrP does not have a role in calcium homeostasis in nursing mothers. Furthermore, additional studies in hypoparathyroid nursing mothers should be performed.
我们在15名健康女性开始母乳喂养后的三天内以及完成哺乳后的一小时内，测量了她们血清中的甲状旁腺激素相关蛋白（PTHrP）。采用了一种灵敏的免疫放射分析方法，该方法可测量至少包含前74个氨基酸的N端PTHrP。我们发现所有患者的PTHrP值均正常。一名选择不进行母乳喂养的甲状旁腺功能减退女性在分娩前一天和分娩后两天的值也正常。由于1 - 36个氨基酸或更多的N端PTHrP片段具有生物活性，我们认为在得出PTHrP在哺乳母亲的钙稳态中不起作用的结论之前，有必要使用能测量更小片段的灵敏PTHrP检测方法进行更多研究，并在其他母乳喂养条件下进行调查。此外，还应针对甲状旁腺功能减退的哺乳母亲开展更多研究。
