Endo M, Yoshida S
Department of Anesthesia, Kanto Rosai Hospital, Kawasaki.
Masui. 1995 Apr;44(4):560-2.
We reported anesthetic as well as perioperative management for a patient with Creutzfeldt-Jakob disease, a very rare transmissible neuropathy. A 51 year-old woman was scheduled for extirpation of recurrence of acoustic neurinoma. Three months before the operation, she had complained vertigo. After admission to our hospital, she had become progressively dementiated and developed disturbed consciousness. Anesthesia was induced with thiamylal and maintained with 0.7-1.5% isoflurane, nitrous oxide and oxygen. The anesthetic course was uneventful and the recovery from anesthesia was smooth. Postoperatively dementia progressed and myoclonus of extremeties appeared sixth weeks after the operation. Two months after the operation, a diagnosis of Creutzfeldt-Jakob disease was established by characteristic EEG and clinical course. Anesthesia for a patient with dementia was discussed.
我们报告了一例克雅氏病（一种非常罕见的可传播性神经病变）患者的麻醉及围手术期管理情况。一名51岁女性计划接受听神经瘤复发切除术。术前三个月，她曾抱怨眩晕。入院后，她逐渐出现痴呆，并发展为意识障碍。采用硫喷妥钠诱导麻醉，并用0.7 - 1.5%异氟烷、氧化亚氮和氧气维持麻醉。麻醉过程顺利，麻醉苏醒平稳。术后痴呆进展，术后六周出现肢体肌阵挛。术后两个月，通过特征性脑电图和临床病程确诊为克雅氏病。文中还讨论了痴呆患者的麻醉问题。
