Noguchi A, Hasegawa Y, Sasaki Y, Imaoka S, Hashizume T, Ibuka K, Wakasugi S, Nakano S
Department of Nuclear Medicine, Center for Adult Diseases, Osaka.
Kaku Igaku. 1995 Apr;32(4):419-26.
In 14 patients with hepatic tumors, liver volume and liver function indices were studied by 99mTc-GSA liver scintigraphy before and after hepatectomy. The liver volume measured by 99mTc-GSA SPECT was significantly decreased after surgery in all 14 patients (p < 0.001). Postsurgically, 7 patients showed an increase of greater than 10% in the LU15 value, while 3 showed a decrease of 10% in the LU15 value, while 3 showed a decrease of 10%. Two patients showed a decrease of greater than 10% in the HH15 value after surgery. The changes in LU15 after surgery were inversely correlated with those in HH15. The present findings clarified that in several cases of surgically treated hepatic tumors, 99mTc-GSA indices of liver function generally thought to indicate the size of the functioning liver cell mass were distinctly improved after surgery in comparison with those before surgery, despite the postoperative decrease in the liver volume. Furthermore, the results of a 99mTc-GSA SPECT study separately measuring the volume of the unilateral hepatic lobe and its radioactivity uptake, indicated that regeneration of the functioning liver cells often occurred in the entire liver. 99mTc-GSA scintigraphy appears to be a valuable method for evaluating changes in both the liver volume and the liver function indices after hepatectomy.
对14例肝肿瘤患者在肝切除术前、后采用99mTc-GSA肝脏闪烁扫描法研究肝脏体积和肝功能指标。14例患者术后通过99mTc-GSA SPECT测量的肝脏体积均显著减小（p < 0.001）。术后，7例患者的LU15值升高超过10%，3例患者的LU15值降低10%，2例患者术后HH15值降低超过10%。术后LU15的变化与HH15的变化呈负相关。目前的研究结果表明，在几例接受手术治疗的肝肿瘤患者中，尽管术后肝脏体积减小，但通常认为可指示功能性肝细胞团大小的99mTc-GSA肝功能指标在术后与术前相比明显改善。此外，一项99mTc-GSA SPECT研究分别测量单侧肝叶体积及其放射性摄取的结果表明，功能性肝细胞的再生常发生于整个肝脏。99mTc-GSA闪烁扫描似乎是评估肝切除术后肝脏体积和肝功能指标变化的一种有价值的方法。
