Sil'kis I G, Rapoport S Sh, Veber N V
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Neurosci Behav Physiol. 1995 Jan-Feb;25(1):15-24. doi: 10.1007/BF02359245.
The long-term postsynaptic changes of mono- and polysynaptic reactions of neighboring neurons of the MC were investigated following conditioning tetanization of different afferent inputs. Modifiable synapses were found both in the cells investigated and in local neuronal circuits which included the cells, i.e., possibly in interneurons. Alternating and concurrent conditioning of thalamocortical and corticocortical input showed that, depending upon the modality of the conditioned input, the tetanization parameters, the character of the distribution of the afferents, as well as on the character of local circuits which include excitatory and inhibitory interneurons, the effectiveness of synaptic inputs to neighboring neurons varies diversely, as a result of which a specific pattern of interneuronal connections forms in a microsegment of cortex, a pattern which may be maintained over the course of tens of minutes. It was found that modifiable synapses of different types may function simultaneously in one and the same micronetwork. The investigation may be of interest in developing models of memory and learning.
在对不同传入输入进行条件性强直刺激后，研究了运动皮质（MC）相邻神经元单突触和多突触反应的长期突触后变化。在所研究的细胞以及包含这些细胞的局部神经回路（即可能在中间神经元中）均发现了可修饰的突触。对丘脑皮质和皮质皮质输入进行交替和同时条件刺激表明，取决于条件输入的模式、强直刺激参数、传入纤维分布的特征以及包含兴奋性和抑制性中间神经元的局部回路的特征，相邻神经元突触输入的有效性会有不同变化，结果在皮质的一个微节段中形成了特定的中间神经元连接模式，这种模式可能在数十分钟内得以维持。研究发现，不同类型的可修饰突触可能在同一个微网络中同时发挥作用。该研究对于开发记忆和学习模型可能具有重要意义。
