Jensen M, Basun H, Lannfelt L
Karolinska Institute, Department of Clinical Neuroscience, Huddinge University Hospital, Sweden.
Neurosci Lett. 1995 Feb 17;186(2-3):189-91. doi: 10.1016/0304-3940(95)11297-a.
One of the pathological features in Alzheimer's disease (AD) is neurofibrillary tangles in the brain. The main constituent of tangles is the microtubuli-associated protein tau in a hyperphosphorylated state. Tau is also released into cerebrospinal fluid (CSF), and in this study we have used an enzyme linked immunosorbent assay to measure tau in CSF from AD and control cases. Our findings show that tau levels in AD cases are significantly elevated compared to healthy control individuals. We suggest that tau may serve as a biochemical marker of Alzheimer's disease.
阿尔茨海默病（AD）的病理特征之一是大脑中的神经原纤维缠结。缠结的主要成分是处于高度磷酸化状态的微管相关蛋白tau。Tau蛋白也会释放到脑脊液（CSF）中，在本研究中，我们使用酶联免疫吸附测定法来测量AD患者和对照者脑脊液中的tau蛋白。我们的研究结果表明，与健康对照个体相比，AD患者的tau蛋白水平显著升高。我们认为tau蛋白可能作为阿尔茨海默病的生化标志物。
