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四氧嘧啶糖尿病大鼠大脑中的去甲肾上腺素和肾上腺素水平。

Norepinephrine and epinephrine levels in the brain of alloxan diabetic rats.

作者信息

Ramakrishnan R, Namasivayam A

机构信息

Department of Physiology, Dr. ALMPost Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, India.

出版信息

Neurosci Lett. 1995 Feb 17;186(2-3):200-202. doi: 10.1016/0304-3940(95)11315-n.

Abstract

Thirty days after induction of experimental diabetes the brain catecholamines namely, norepinephrine (NE) and epinephrine (E) were studied in discrete brain regions (striatum, hippocampus, hypothalamus, midbrain, pons and medulla, cerebellum and cerebral cortex) in control, alloxan-diabetic untreated and insulin-treated diabetic rats. E showed significant increase in striatum, hippocampus and hypothalamus, whereas NE was increased in hypothalamus, and decreased in pons and medulla significantly in untreated diabetic rats. These effects were not seen in the insulin-treated diabetic rats.

摘要

在诱导实验性糖尿病30天后,对对照组、未治疗的四氧嘧啶糖尿病大鼠和胰岛素治疗的糖尿病大鼠的离散脑区(纹状体、海马体、下丘脑、中脑、脑桥和延髓、小脑和大脑皮层)中的脑儿茶酚胺,即去甲肾上腺素(NE)和肾上腺素(E)进行了研究。在未治疗的糖尿病大鼠中,E在纹状体、海马体和下丘脑中显著增加,而NE在下丘脑中增加,在脑桥和延髓中显著减少。这些效应在胰岛素治疗的糖尿病大鼠中未观察到。

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