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Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes.

作者信息

Henry D J, Chavkin C

机构信息

Department of Pharmacology, University of Washington, Seattle 98195, USA.

出版信息

Neurosci Lett. 1995 Feb 17;186(2-3):91-4. doi: 10.1016/0304-3940(95)11289-9.

DOI:10.1016/0304-3940(95)11289-9
PMID:7777206
Abstract

The neuronal cannabinoid receptor clone was expressed of saturable [3H]WIN 55,212-2 binding sites. Co-expression of the cannabinoid receptor with cRNA coding for the G-protein-gated inwardly rectifying K+ channel (GIRK1) resulted in oocytes exhibiting large inward K+ currents in response to the cannabinoid agonist WIN 55,212-2. The activation of the potassium current by WIN 55,212-2 was dose-dependent with an EC50 of 630 nM. These results suggest that activation of inwardly rectifying K+ channels may be an additional effector mechanism for brain cannabinoid receptors.

摘要

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