Brugère-Picoux J, Chatelain J
Pathologie Médicale du Bétail et des Animaux de Basse-Cour, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France.
Pathol Biol (Paris). 1995 Feb;43(2):81-90.
Scrapie in sheep and goat is the prototype of the group of the transmissible spongiform encephalopathies which affect man and some animal species, notably other ruminants with bovine spongiform encephalopathy (BSE) and chronic wasting disease of wild ruminants. Transmissible mink encephalopathy (TME) is a rare disease of ranch-raised mink caused by exposure to a contaminated food ingredient in the ration scrapie, unrecognised BSE-like disease...). There is clinical and pathological similarities between TME and scrapie. These diseases share the following characteristics: a prolonged incubation period; a progressive, debilitating, neurological illness (always fatal); pathological changes confined to the central nervous system (vacuolisation, neurological loss, astrocytosis); the presence of scrapie-associated-fibrils (SAF) in brain tissue; and absence of detectable inflammatory or immune responses. The genetic origin of scrapie in sheep and the natural transmission of these spongiform encephalopathies are discussed.
绵羊和山羊的痒病是可传播性海绵状脑病的原型，这类疾病会影响人类和一些动物物种，尤其是其他反刍动物，如患有牛海绵状脑病（BSE）的牛和野生反刍动物的慢性消耗病。可传播性水貂脑病（TME）是一种养殖水貂的罕见疾病，由食用含有痒病污染饲料成分的日粮引起，是一种未被识别的类似BSE的疾病……TME和痒病在临床和病理上有相似之处。这些疾病具有以下共同特征：潜伏期长；进行性、使人衰弱的神经疾病（总是致命的）；病理变化局限于中枢神经系统（空泡化、神经细胞丧失、星形细胞增多）；脑组织中存在痒病相关纤维（SAF）；以及没有可检测到的炎症或免疫反应。本文讨论了绵羊痒病的遗传起源以及这些海绵状脑病的自然传播。
