Trappe H J, Wenzlaff P
Department of Cardiology, University Hospital Hannover, Germany.
Pacing Clin Electrophysiol. 1995 Mar;18(3 Pt 2):622-31. doi: 10.1111/j.1540-8159.1995.tb02573.x.
The prognosis of patients with severely impaired left ventricular function is poor, with an annual mortality rate of about 50%, and the majority die from sudden cardiac death. Heart transplantation is an accepted therapy for patients with end-stage heart disease; however, about 30% of candidates for transplantation die from sudden cardiac death while on the waiting list. It has been shown that implantable cardioverter defibrillator (ICD) therapy has a low surgical mortality and is highly effective in the prevention of sudden death. Therefore, prophylactic ICD implantation may prevent sudden death in patients with end-stage heart disease while on the waiting list, and it is highly probable that patients with an ICD have a greater chance of survival until a donor heart becomes available. However, this hypothesis still has to be proven by prospective studies.
左心室功能严重受损的患者预后较差，年死亡率约为50%，且大多数死于心源性猝死。心脏移植是终末期心脏病患者公认的治疗方法；然而，约30%的移植候选者在等待名单上时死于心源性猝死。已表明植入式心律转复除颤器（ICD）治疗手术死亡率低，且在预防猝死方面非常有效。因此，预防性植入ICD可能会预防终末期心脏病患者在等待名单上时发生猝死，且植入ICD的患者极有可能有更大机会存活至获得供体心脏。然而，这一假设仍有待前瞻性研究证实。
