Gandour-Edwards R, Kapadia S B, Janecka I P, Martinez A J, Barnes L
Department of Pathology, University of California, Davis, USA.
Mod Pathol. 1995 Feb;8(2):160-4.
The biologic behavior of invasive pituitary adenomas is poorly understood and appears to be intermediate between intrasellar adenomas and pituitary carcinoma. Utilizing immunohistochemistry on tissue sections, we examined 10 invasive pituitary adenomas involving the sphenoid sinus with a panel of cellular and molecular markers and compared the results with 10 noninvasive pituitary adenomas and five normal pituitary glands. The panel included Ki-67 and PCNA (proliferation cell nuclear antigen), cell proliferation indicators; interleukin 6 (IL-6), a multifunctional cytokine; heat shock protein 27 (HSP 27), a stress response protein; and p53, a tumor suppressor gene product. We found strong expression of IL-6 in normal pituitary glands, 20% of noninvasive and 50% of invasive adenomas. HSP 27 was absent in normal glands and present in 10% of noninvasive and 50% of invasive adenomas. The Ki-67 and PCNA proliferation index was above normal but was essentially the same in the two groups. p53 was not detected in any specimens. We propose that both IL-6 and HSP 27 may be markers of biologic aggression in pituitary adenomas.
侵袭性垂体腺瘤的生物学行为目前了解甚少，其表现似乎介于鞍内腺瘤和垂体癌之间。我们运用组织切片免疫组化技术，使用一组细胞和分子标志物对10例侵犯蝶窦的侵袭性垂体腺瘤进行检测，并将结果与10例非侵袭性垂体腺瘤及5个正常垂体进行比较。这组标志物包括细胞增殖指标Ki-67和增殖细胞核抗原（PCNA）、多功能细胞因子白细胞介素6（IL-6）、应激反应蛋白热休克蛋白27（HSP 27）以及肿瘤抑制基因产物p53。我们发现，IL-6在正常垂体、20%的非侵袭性腺瘤及50%的侵袭性腺瘤中呈强表达。HSP 27在正常腺体中未检测到，在10%的非侵袭性腺瘤及50%的侵袭性腺瘤中存在。Ki-67和PCNA增殖指数高于正常水平，但两组间基本相同。所有标本均未检测到p53。我们认为，IL-6和HSP 27都可能是垂体腺瘤生物学侵袭性的标志物。
