Trabelsi F, Hélie R, Bergeron R, Lavoie J M
Département d'éducation physique, Université de Montréal, Québec, Canada.
Physiol Behav. 1995 Apr;57(4):797-802. doi: 10.1016/0031-9384(94)00390-4.
It is well known that several amino acids, such as arginine, are potent stimuli for insulin and glucagon secretion from the pancreas. Recently, vagal arginine sensors, which modulate arginine-induced pancreatic hormone secretion, have been reported to exist in the liver. The present investigation was designed to evaluate the role played by gluconeogenesis in this hepatic influence. To this end, we studied the effects of an intraperitoneal injection of 3-mercaptopicolinic acid (3-MPA), a gluconeogenic inhibitor, on the pancreatic hormonal response induced by intraperitoneal administration of arginine (1 g/kg body mass) to hepatic vagotomized and sham vagotomized rats. Fifteen min following the injection of arginine, the increases in glucose and insulin concentrations were significantly lower in rats with an inhibited gluconeogenesis than in rats with an intact capacity for gluconeogenesis. There were no effects of the hepatic vagotomy on the arginine-induced hormonal responses either with or without the 3-MPA injection. The results suggest that gluconeogenesis is implicated in the hepatic modulation of arginine-induced pancreatic hormone secretion.
众所周知，几种氨基酸，如精氨酸，是胰腺分泌胰岛素和胰高血糖素的有效刺激物。最近，有报道称肝脏中存在调节精氨酸诱导的胰腺激素分泌的迷走神经精氨酸传感器。本研究旨在评估糖异生在这种肝脏影响中所起的作用。为此，我们研究了腹腔注射糖异生抑制剂3-巯基吡啶甲酸（3-MPA）对肝迷走神经切断和假迷走神经切断大鼠腹腔注射精氨酸（1 g/kg体重）诱导的胰腺激素反应的影响。注射精氨酸15分钟后，糖异生受抑制的大鼠的血糖和胰岛素浓度升高明显低于糖异生能力正常的大鼠。无论是否注射3-MPA，肝迷走神经切断对精氨酸诱导的激素反应均无影响。结果表明，糖异生参与了肝脏对精氨酸诱导的胰腺激素分泌的调节。
