Jensen M B, Ejlersen E, Eliasen K R, Løkkegaard H
Nefrologisk afdeling, Amtssygehuset i Herlev.
Ugeskr Laeger. 1995 May 1;157(18):2564-9.
The mortality of critically ill patients who develop acute renal failure (ARF) is persistingly high. We reviewed all patients who developed ARF that required dialysis in a single intensive care unit (n = 167) during the period 1977 to 1989, in order to identify variables with possible influence on outcome. Overall mortality within hospital was 75%. Age above 60 (p < 0.02), requirement for mechanical ventilation (p < 0.0005), requirement for inotropic drugs (p < 0.0005) and increased levels of P-bilirubin (p < 0.005) had negative impacts on survival. Mortality increased significantly from 63% in the early period (1977-1985) to 84% in the late period (1986-1989) (p < 0.001), a rise that could not be explained by a single variable. The patients in the later period were, though, characterized by a higher morbidity with a higher frequency of additional organ failure.
发生急性肾衰竭(ARF)的重症患者死亡率一直居高不下。我们回顾了1977年至1989年期间在单个重症监护病房发生需要透析的ARF的所有患者(n = 167),以确定可能影响预后的变量。院内总死亡率为75%。60岁以上(p < 0.02)、需要机械通气(p < 0.0005)、需要使用血管活性药物(p < 0.0005)以及血清胆红素水平升高(p < 0.005)对生存有负面影响。死亡率从早期(1977 - 1985年)的63%显著增加到后期(1986 - 1989年)的84%(p < 0.001),这种上升无法用单一变量来解释。不过,后期患者的特点是发病率较高,伴有其他器官衰竭的频率更高。