Shepherd J, Shepherd C, Tonozzi C, Boysen E
Department of Family Medicine, University of Colorado, Denver 80202, USA.
J Am Board Fam Pract. 1995 Mar-Apr;8(2):130-3.
Although other drugs can be used in the prophylaxis and treatment of HIV-infected persons, family physicians will prescribe co-trimoxazole frequently. These providers need to recognize the overall increased frequency of adverse reactions to this drug in this population and the potential for severe hypersensitivity effects requiring intensive hospital care. While the exact importance re-exposure has in causing this reaction remains unclear, certainly providers must pay particular attention to patients who have had any earlier sensitivity to the drug before treatment is resumed. Desensitization therapy has been used successfully in some HIV-positive individuals, even after severe reactions; however, this case again teaches the need for prudence in the use of all pharmacological agents.
虽然其他药物可用于预防和治疗艾滋病毒感染者，但家庭医生经常会开复方新诺明。这些医疗人员需要认识到该人群中对这种药物不良反应的总体发生率增加，以及可能出现需要重症监护的严重过敏反应。虽然再次接触药物在引发这种反应的确切重要性尚不清楚，但在重新开始治疗前，医疗人员肯定必须特别关注曾对该药物有过任何早期过敏反应的患者。脱敏疗法已在一些艾滋病毒呈阳性的个体中成功应用，即使是在发生严重反应之后；然而，这个病例再次表明在使用所有药物时都需要谨慎。
