Hata T, Manabe A, Hata K, Kitao M
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
Am J Perinatol. 1995 Mar;12(2):80-1. doi: 10.1055/s-2007-994408.
Nifedipine has been used to treat hypertension in pregnancy, and does not influence fetal or uteroplacental circulations in patients with preeclampsia. A 29-year-old multi-gravid woman presented at 32 weeks' gestation with significant elevation of her blood pressure. After sublingual administration of nifedipine, the blood pressure decreased from 208/122 to 136/96 mm Hg at 30 minutes. In her growth-retarded fetus with abnormal flow velocity waveforms, pulsatility index values for middle cerebral artery and umbilical artery did not change; however, peak systolic velocities, end-diastolic velocities, and time-averaged mean peak velocities for these arteries became significantly elevated. Simultaneously, severe variable decelerations and late decelerations occurred. The adverse effect of nifedipine on fetal circulation might occur in a growth-retarded fetus with abnormal flow velocity waveforms.
硝苯地平已被用于治疗妊娠期高血压，且对先兆子痫患者的胎儿或子宫胎盘循环无影响。一名29岁的经产妇在妊娠32周时出现血压显著升高。舌下含服硝苯地平后，30分钟时血压从208/122降至136/96 mmHg。在其生长受限且血流速度波形异常的胎儿中，大脑中动脉和脐动脉的搏动指数值未发生变化；然而，这些动脉的收缩期峰值速度、舒张末期速度和时间平均平均峰值速度显著升高。同时，出现了严重的变异减速和晚期减速。硝苯地平对胎儿循环的不良影响可能发生在生长受限且血流速度波形异常的胎儿中。
