抗氧化剂对阿霉素诱导的微粒体脂质过氧化的影响。
Effect of antioxidants on adriamycin-induced microsomal lipid peroxidation.
作者信息
Hida H, Coudray C, Calop J, Favier A
机构信息
Groupe de Recherche sur les Pathologies Oxydatives (GREPO) Laboratoire de Pharmacie Clinique et Biotechniques, UJF, Faculté de Pharmacie, La Tronche, France.
出版信息
Biol Trace Elem Res. 1995 Jan-Mar;47(1-3):111-6. doi: 10.1007/BF02790107.
Adriamycin (25 microM) stimulated NADPH-dependent microsomal lipid peroxidation about fourfold over control values. The tested antioxidants, zinc, superoxide dismutase, vitamin E, and desferrioxamine (Desferal) inhibited Adriamycin-enhanced lipid peroxidation to varying degrees. Others antioxidants, e.g., glutathione, catalase, and selenium, were found to have no effects. Our in vitro studies suggest that adriamycin effect is mediated by a complex oxyradical cascade involving superoxide, hydroxyl radical, and small amounts of iron.
阿霉素（25微摩尔）刺激的NADPH依赖性微粒体脂质过氧化比对照值高出约四倍。所测试的抗氧化剂，锌、超氧化物歧化酶、维生素E和去铁胺（去铁敏）不同程度地抑制了阿霉素增强的脂质过氧化。其他抗氧化剂，如谷胱甘肽、过氧化氢酶和硒，未发现有作用。我们的体外研究表明，阿霉素的作用是由涉及超氧化物、羟基自由基和少量铁的复杂氧自由基级联介导的。
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