King D, Davies K N, Slee A, Silas J H
Clatterbridge Hospital, Wirral, Merseyside.
Br J Clin Pract. 1995 May-Jun;49(3):123-5.
The use of warfarin and aspirin for the primary prevention of stroke in elderly patients with atrial fibrillation (AF) is controversial. To establish current practice we circulated a questionnaire to 300 geriatricians (G) and 300 cardiologists (C). The response rates were 47% G and 51% C. Most physicians prescribed warfarin in AF associated with mitral stenosis (G vs C, 86% vs 89%, NS). Cardiologists were more likely to prescribe warfarin in AF associated with dilated cardiomyopathy (G vs C, 52% vs 86%, P < 0.01). A minority would prescribe warfarin in aortic valve disease and AF (G vs C, 37% vs 24%, P < 0.05) and lone AF (G vs C, 10% vs 26%, P < 0.01). Aspirin was favoured in aortic valve disease and lone AF. The cardiologists were less reluctant to use warfarin in the young and more likely to electrically cardiovert the young with chronic AF.
华法林和阿司匹林用于老年房颤(AF)患者卒中一级预防存在争议。为了解当前的治疗情况,我们向300名老年病科医生(G)和300名心脏病专家(C)发放了调查问卷。老年病科医生的回复率为47%,心脏病专家的回复率为51%。大多数医生在二尖瓣狭窄相关的房颤中开具华法林(老年病科医生与心脏病专家,86%对89%,无显著差异)。心脏病专家在扩张型心肌病相关的房颤中更倾向于开具华法林(老年病科医生与心脏病专家,52%对86%,P<0.01)。少数医生会在主动脉瓣疾病合并房颤(老年病科医生与心脏病专家,37%对24%,P<0.05)以及孤立性房颤(老年病科医生与心脏病专家,10%对26%,P<0.01)中开具华法林。阿司匹林在主动脉瓣疾病和孤立性房颤中更受青睐。心脏病专家在年轻人中使用华法林时顾虑较少,且更倾向于对年轻的慢性房颤患者进行电复律。