多氯联苯对成年大鼠睾丸间质细胞体外悬浮培养时雄激素生成的影响。
Effect of PCBs on androgen production by suspension of adult rat Leydig cells in vitro.
作者信息
Kovacević R, Vojinović-Miloradov M, Teodorović I, Andrić S
机构信息
Institute of Biology, Faculty of Sciences, University of Novi Sad, Serbia.
出版信息
J Steroid Biochem Mol Biol. 1995 Jun;52(6):595-7. doi: 10.1016/0960-0760(95)00060-d.
The effects of PCBs (mixture of 2, 3, 4, 5-tetra; 2, 2', 4, 5, 5'-penta; 2, 2', 3, 3', 6, 6'-hexa and 2, 2', 3, 3', 4, 4', 5, 5'-octa congeners) on androgen production were investigated by suspension of Leydig cells from adult rat testis. hCG-stimulated androgen production was significantly inhibited by PCBs while progesterone level was not affected. Progesterone supported testosterone production was also decreased by PCBs, while conversion of androstenedione to testosterone was unchanged. These results suggest that the activity of microsomal enzyme C21 side-chain cleavage P450 was decreased by PCB treatment of Leydig cells in vitro.
通过悬浮成年大鼠睾丸的莱迪希细胞，研究了多氯联苯（2,3,4,5-四氯联苯；2,2',4,5,5'-五氯联苯；2,2',3,3',6,6'-六氯联苯和2,2',3,3',4,4',5,5'-八氯联苯的混合物）对雄激素生成的影响。多氯联苯显著抑制了人绒毛膜促性腺激素刺激的雄激素生成，而孕酮水平未受影响。多氯联苯还降低了孕酮支持的睾酮生成，而雄烯二酮向睾酮的转化未发生变化。这些结果表明，体外多氯联苯处理莱迪希细胞会降低微粒体酶C21侧链裂解P450的活性。
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