Zhang L X, Kan G Q, Tu D H, Li J S, Liu X X
Beijing Research Institute for Tuberculosis Control, China.
Tuber Lung Dis. 1995 Apr;76(2):100-3. doi: 10.1016/0962-8479(95)90549-9.
The tuberculosis control programme of Beijing.
To observe the trend of initial drug resistance of tubercle bacilli and to try to correlate it with the Beijing tuberculosis control programme.
Susceptibility testing of randomly collected isolates of positive sputum culture from new patients with pulmonary tuberculosis without a history of prior antituberculosis therapy, in 1962 and continuously since 1978. Collection of treatment data from the Beijing tuberculosis control programme.
The trend of initial drug resistance in Beijing began to decline in 1978. The Beijing tuberculosis treatment programme has been very successful, resulting in rapid reduction of prevalence of smear-positive cases.
It appears that the trend of initial drug resistance correlates with progress made in the implementation of the successful tuberculosis programme in Beijing. It is recommended that continuous observation of initial drug resistance be one of the indices of tuberculosis surveillance.
北京市结核病控制项目。
观察结核杆菌初始耐药性的变化趋势，并尝试将其与北京市结核病控制项目相关联。
对1962年及自1978年起连续随机收集的、无既往抗结核治疗史的新发肺结核患者痰培养阳性分离株进行药敏试验。收集北京市结核病控制项目的治疗数据。
北京市结核杆菌初始耐药性趋势于1978年开始下降。北京市结核病治疗项目非常成功，痰涂片阳性病例患病率迅速降低。
看来结核杆菌初始耐药性趋势与北京市成功实施结核病项目所取得的进展相关。建议将持续观察初始耐药性作为结核病监测指标之一。
