Seiberg M, Marthinuss J
Skin Biology Research Center, R.W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869-0602, USA.
Dev Dyn. 1995 Mar;202(3):294-301. doi: 10.1002/aja.1002020308.
Clusterin/TRPM-2 is a sulfated glycoprotein that is expressed in many tissues. Independently cloned and isolated by several laboratories, it bears many names, and has been shown to be involved in many processes. These include cell-cell adhesion and aggregation, inhibition of complement cytolysis, programmed cell death and apoptosis, tissue remodeling, and terminal differentiation. The hair follicle undergoes cycles of growth, regression, and rest, which involve both tissue remodeling and programmed cell death. To identify whether clusterin expression is involved in hair growth and cycling, we studied the expression of clusterin throughout the hair cycle. We demonstrate that clusterin is expressed during the growth phase of the hair cycle. We found no correlation between clusterin expression and the apoptotic regression of the hair follicle. Using immunohistochemistry we localized clusterin to the inner root sheath of the follicle. This suggests that clusterin might be involved in the morphogenesis and differentiation of the hair follicle. We propose that clusterin has a role in the maintenance of the layered structure of the hair follicle, and in the interactions between the inner root sheath and both the outer root sheath and the
聚集素/TRPM-2是一种在许多组织中表达的硫酸化糖蛋白。它由多个实验室独立克隆和分离，有许多名称，并且已被证明参与许多过程。这些过程包括细胞间黏附和聚集、补体细胞溶解抑制、程序性细胞死亡和凋亡、组织重塑以及终末分化。毛囊经历生长、退化和休止的周期，这涉及组织重塑和程序性细胞死亡。为了确定聚集素的表达是否参与毛发生长和周期，我们研究了聚集素在整个毛发周期中的表达。我们证明聚集素在毛发周期的生长期表达。我们发现聚集素表达与毛囊的凋亡性退化之间没有相关性。通过免疫组织化学，我们将聚集素定位到毛囊的内根鞘。这表明聚集素可能参与毛囊的形态发生和分化。我们提出聚集素在维持毛囊的分层结构以及内根鞘与外根鞘之间的相互作用中起作用，并且在……
