Bridges C G, Taylor D L, Kang M S, Brennan T M, Tyms A S
MRC Collaborative Centre, London, UK.
Glycobiology. 1995 Mar;5(2):243-7. doi: 10.1093/glycob/5.2.243.
The antiviral clinical candidate 6-O-butanoyl castanospermine (MDL 28,574), an alpha-glucosidase 1 inhibitor, was examined for its effect on elementary parameters of immune function. It did not affect the mitogenic response of uninfected human mononuclear leukocytes or the detection of a range of cell surface markers, with the exception of the integrin LFA-1 (CD18/CD11a), which was reduced, after cell growth in vitro. The detection of LFA-1 was also reduced on both human and murine cells after oral administration of the compound to xenochimaeric or normal mice, respectively. Altered LFA-1 expression or function may contribute to reduced cell adhesion and the observed reduction in the in vitro allogeneic response by uninfected cells, as well as the previously described prevention of cell conjugate and HIV-induced syncytium formation.
抗病毒临床候选药物6-O-丁酰基栗精胺（MDL 28,574）是一种α-葡糖苷酶1抑制剂，对其免疫功能基本参数的影响进行了研究。它不影响未感染人单核白细胞的促有丝分裂反应，也不影响一系列细胞表面标志物的检测，但整合素淋巴细胞功能相关抗原1（LFA-1，CD18/CD11a）除外，在体外细胞生长后其表达减少。分别给异种嵌合体或正常小鼠口服该化合物后，人和鼠细胞上LFA-1的检测也减少。LFA-1表达或功能的改变可能导致细胞黏附减少以及未感染细胞体外同种异体反应的降低，还可能导致之前描述的细胞结合物形成及HIV诱导的合胞体形成受到抑制。
