Agrawal S, Kishore R
Sanjay Gandhi Postgraduate Institute of Medical Sciences, Uttar Pradesh, India.
Natl Med J India. 1995 May-Jun;8(3):121-3.
The defective recognition of foetal alloantigens by the maternal immune system is associated with recurrent pregnancy failure and may be prevented by boosting the maternal immune response with paternal or third party leucocyte immunization. The mechanism by which this process achieves success is not known. Clinical trials on recurrent spontaneous abortion have shown an up to 70% successful pregnancy rate after immunotherapy but the importance of this is unclear because there have been success rates of between 29% and 76% even in the control population. These variations could be due to small sample sizes and heterogeneity in the populations studied as well as co-intervention by the placebo. This article reviews the state-of-the-art for immunotherapy and discusses its mechanism of action in the prevention of recurrent foetal loss.
母体免疫系统对胎儿同种异体抗原的识别缺陷与复发性流产相关，通过父方或第三方白细胞免疫增强母体免疫反应可能预防这种情况。该过程取得成功的机制尚不清楚。复发性自然流产的临床试验显示，免疫治疗后妊娠成功率高达70%，但其重要性尚不清楚，因为即使在对照组人群中成功率也在29%至76%之间。这些差异可能是由于研究人群样本量小和异质性以及安慰剂的共同干预所致。本文综述了免疫治疗的最新进展，并讨论了其在预防复发性胎儿丢失中的作用机制。
