Keller A, Bömches B, Kandt D
Fortschr Med. 1995 May 10;113(13):197-202.
The present study was conducted to investigate the therapeutic effect of long-term treatment with a slow-release theophylline preparation on the pulmonary functions FEV1 and peak exspiratory flow (PEF). A total of 908 patients took part in this open multicenter study. Treatment with the slow-release theophylline resulted in an increase of FEV1 and PEF of about 20% in asthma and between 11% and 14% in COPD. Apart from theophylline itself, the galenic nature of the slow-release formulation also contributed to the therapeutic effect.
本研究旨在探讨长效缓释型茶碱制剂对肺功能第一秒用力呼气容积（FEV1）和呼气峰值流速（PEF）的治疗效果。共有908例患者参与了这项开放性多中心研究。使用缓释型茶碱治疗后，哮喘患者的FEV1和PEF增加了约20%，慢性阻塞性肺疾病（COPD）患者的FEV1和PEF增加了11%至14%。除茶碱本身外，缓释制剂的药剂学性质也有助于产生治疗效果。
