Weinstein G D, McCullough J L
J Invest Dermatol. 1976 Jul;67(1):26-30. doi: 10.1111/1523-1747.ep12512476.
The successful treatment of psoriasis with folic acid antagonists during the past 25 years has led to extensive research in the areas of cytokinetics and chemotherapy. In this paper we shall review selected aspects of these topics relevant to the treatment of psoriasis. The effectiveness of methotrexate treatment of psoriasis can be related to both the hyperproliferative cytokinetics of psoriasis and an increased biochemical sensitivity of psoriatic epidermal cells to this drug. Future research goals in chemotherapy of psoriasis include (a) optimizing drug schedules for available drugs; (b) identifying other susceptible biochemical points of selective drug attack; (c) identifying secondary advantages in order to facilitate selective drug action in psoriasis, such as ultraviolet light therapy in combination with a systemic drug; and (d) developing topically effective chemotherapeutic agents. Approaches to research on topical therapy are reviewed with specific reference to animal testing models for psoriasis and percutaneous penetration of topically applied agents.
在过去25年中，使用叶酸拮抗剂成功治疗银屑病引发了细胞动力学和化疗领域的广泛研究。在本文中，我们将回顾这些与银屑病治疗相关主题的选定方面。甲氨蝶呤治疗银屑病的有效性既与银屑病的过度增殖细胞动力学有关，也与银屑病表皮细胞对该药物的生化敏感性增加有关。银屑病化疗的未来研究目标包括：（a）优化现有药物的用药方案；（b）确定其他选择性药物攻击的敏感生化靶点；（c）确定次要优势，以促进在银屑病中进行选择性药物作用，如紫外线疗法与全身性药物联合使用；（d）开发局部有效的化疗药物。本文回顾了局部治疗的研究方法，并特别提及了银屑病动物试验模型和局部应用药物的经皮渗透。
