Padgett B L, Walker D L, ZuRhein G M, Hodach A E, Chou S M
J Infect Dis. 1976 Jun;133(6):686-90. doi: 10.1093/infdis/133.6.686.
Brain tissue from seven patients with progressive multifocal leukoencephalopathy was tested for the presence of papovaviruses. JC virus, ahuman papovavirus, was identified in all seven cases. Virus was isolated in tissue culture from extracts from each of four patients and was detected by immunofluorescence in sections from the other three. The new osolates were indistinguishable from the prototypical JC strain serologically and in all biological characteristics examined. Thus JC virus has, to date, been associated with 20 cases of progressive multifocal leukoencephalopathy.
对7例进行性多灶性白质脑病患者的脑组织进行了乳头多瘤空泡病毒检测。在所有7例病例中均鉴定出JC病毒，一种人乳头多瘤空泡病毒。从4例患者的提取物中在组织培养中分离出病毒，另外3例通过免疫荧光在切片中检测到病毒。新分离株在血清学和所有检测的生物学特性方面与原型JC株无法区分。因此，迄今为止，JC病毒已与20例进行性多灶性白质脑病相关。
