Elliott H L
Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK.
J Hum Hypertens. 1995 Mar;9 Suppl 1:S29-32.
Clinical studies have shown that calcium antagonist drugs interfere with the reactivity of vascular smooth muscle and thereby attenuate the pressor responses to adrenergic and non-adrenergic vasoconstrictor agents. It is, therefore, possible to explore the extent and duration of calcium channel blockade by studying the magnitude and time course of the attenuation of pressor responses. The effects of three long-acting calcium antagonists, amlodipine, lacidipine and nifedipine GITS (gastrointestinal therapeutic system), on vascular reactivity were assessed over 24h and 48h dosage intervals. It was shown that all three agents attenuate the vasoconstrictor responses to both adrenergic and non-adrenergic stimuli. However, amlodipine and nifedipine GITS were found to suppress vascular reactivity more consistently than lacidipine over 24h. Extending the analysis to 48h after dosing showed that amlodipine had the most consistent effect.
临床研究表明，钙拮抗剂药物会干扰血管平滑肌的反应性，从而减弱对肾上腺素能和非肾上腺素能血管收缩剂的升压反应。因此，通过研究升压反应减弱的程度和时间过程，有可能探索钙通道阻滞的程度和持续时间。在24小时和48小时的给药间隔内，评估了三种长效钙拮抗剂氨氯地平、拉西地平和硝苯地平胃肠道治疗系统（GITS）对血管反应性的影响。结果表明，所有三种药物均能减弱对肾上腺素能和非肾上腺素能刺激的血管收缩反应。然而，发现在24小时内，氨氯地平和硝苯地平GITS比拉西地平更能持续抑制血管反应性。将分析扩展至给药后48小时表明，氨氯地平的作用最为持续。
