3,4-二羟基苯乙酮（3,4-DHAP）对犬缺氧性肺血管和体循环血管反应的影响。

Effects of 3,4-dihydroxyacetophenone (3,4-DHAP) on hypoxic pulmonary and systemic vascular response in dogs.

作者信息

Ullah F, Wang D X, Ming Z, Yu S B

机构信息

Department of Pathophysiology, Tongji Medical University, Wuhan.

出版信息

J Tongji Med Univ. 1995;15(1):26-30. doi: 10.1007/BF02887880.

DOI:10.1007/BF02887880

PMID:7783259

Abstract

The effects of 3,4-DHAP on hypoxic pulmonary and systemic vascular responses were studied in anaesthetized dogs. The percentage change in pulmonary vascular resistance (delta PVR %) and that in systemic vascular resistance (delta SVR %) induced by 5 min hypoxia decreased significantly. 3,4-DHAP in doses of 1 mg/kg, 3 mg/kg, and 10 mg/kg i.v. caused a decrease in delta PVR% from the control value of 47.27 +/- 22.27% to 24.62 +/- 21.76%, 18.15 +/- 18.73%, and 24.10 +/- 19.76% respectively, and a decrease in delta SVR % from the control value of 12.91 +/- 7.39 % to -0.34 +/- 12.70%, -2.11 +/- 12.76%, and -2.37 +/- 15.52 % respectively. The results showed that 3,4-DHAP could decrease the hypoxic responses of pulmonary and systemic blood vessels. But it did not change delta PVR % or delta SVR % in dose of 30 mg/kg, neither did it influence the heart rate, cardiac output or cerebral blood flow during hypoxia in all the doses used.

摘要

在麻醉犬中研究了3,4-二羟基苯丙酮（3,4-DHAP）对缺氧性肺血管和体循环血管反应的影响。5分钟缺氧诱导的肺血管阻力变化百分比（δPVR%）和体循环血管阻力变化百分比（δSVR%）显著降低。静脉注射剂量为1mg/kg、3mg/kg和10mg/kg的3,4-DHAP分别使δPVR%从对照值47.27±22.27%降至24.62±21.76%、18.15±18.73%和24.10±19.76%，使δSVR%从对照值12.91±7.39%分别降至-0.34±12.70%、-2.11±12.76%和-2.37±15.52%。结果表明，3,4-DHAP可降低肺血管和体循环血管的缺氧反应。但30mg/kg剂量的3,4-DHAP既未改变δPVR%或δSVR%，在所有使用剂量下也未影响缺氧期间的心率、心输出量或脑血流量。