Alballa S R
Department of Medicine, College of Medicine, King Saud University, Saudi Arabia.
J Trop Med Hyg. 1995 Jun;98(3):185-9.
There have been indications that human brucellosis is widely distributed in Saudi Arabia. In order to assess the situation in the south, and as a part of a nationwide prevalence survey, a sample of 4900 subjects was randomly selected for a house-to-house survey. Investigations included an interview, clinical examination and blood sampling for antibody titre determinations. Blood samples were first screened for Brucella antibodies by a microplate agglutination test to measure the exposed rate. Reactive sera were further analysed by the standard tube agglutination and 2-mercaptoethanol tests. A total of 4794 completed the study. Results of laboratory tests indicated that a significant proportion of the population in the southern region (19.2%) had serological evidence of exposure to Brucella antigen, and 2.3% had active disease. Direct contact with domestic animals and consumption of raw products of animal origin were identified as the main risk factors.
有迹象表明，人类布鲁氏菌病在沙特阿拉伯广泛分布。为了评估该国南部的情况，并作为全国患病率调查的一部分，随机抽取了4900名受试者进行挨家挨户的调查。调查内容包括访谈、临床检查和采集血样以测定抗体滴度。首先通过微量板凝集试验对血样进行布鲁氏菌抗体筛查，以测量暴露率。对反应性血清进一步采用标准试管凝集试验和2-巯基乙醇试验进行分析。共有4794人完成了研究。实验室检测结果表明，南部地区相当一部分人口（19.2%）有接触布鲁氏菌抗原的血清学证据，2.3%患有活动性疾病。直接接触家畜和食用动物源性生鲜产品被确定为主要风险因素。
