Okubo T, Suzuki T, Fujita K, Iyobe S, Inoue M
Laboratory of Drug Resistance in Bacteria, Gunma University School of Medicine.
Jpn J Antibiot. 1995 Apr;48(4):548-52.
Postantibiotic effects (PAE's) of macrolide antibiotics were determined for Staphylococcus aureus and Enterococcus faecalis using viable counting and Bioscreen C method and the two methods were compared. No major differences between the two methods were observed. The Bioscreen C method was less laborious than the viable counting. The durations of PAE for S. aureus following exposures to erythromycin (EM), josamycin (JM) and rokitamycin (RKM) for 2 hours at twice the MICs were in ranges of 0.85 to 1.45, 2.36 to 3.48 and 1.93 to 5.45 hours, respectively. A definite PAE of 1.0 to 5.8 hours was also observed in E. faecalis strains exposed for 2 hours to EM, JM and RKM at twice the MICs.
采用活菌计数法和Bioscreen C法测定了大环内酯类抗生素对金黄色葡萄球菌和粪肠球菌的抗生素后效应（PAE），并对这两种方法进行了比较。未观察到两种方法之间的主要差异。Bioscreen C法比活菌计数法省力。金黄色葡萄球菌在两倍MIC浓度下分别暴露于红霉素（EM）、交沙霉素（JM）和罗他霉素（RKM）2小时后的PAE持续时间分别为0.85至1.45小时、2.36至3.48小时和1.93至5.45小时。粪肠球菌菌株在两倍MIC浓度下暴露于EM、JM和RKM 2小时后也观察到1.0至5.8小时的明确PAE。
