Kaburaki J, Ikeda Y
Department of Internal Medicine, Keio University School of Medicine.
Rinsho Ketsueki. 1995 Apr;36(4):320-4.
Clinical and serological features in SLE patients with arterial or venous thrombosis were studied. The subjects consisted of 140 patients with SLE who met the revised criteria for the classification of SLE by the American Rheumatism Association. Forty patients (29%) had arterial or venous thrombosis. Arterial thrombosis such as stroke was found in 30 patients, and venous thrombosis such as deep vein thrombosis was seen in 24 patients. Average age at the disease onset was 34.5 +/- 12.5 years old. Renal disorder was found as a clinical feature, and IgG anticardiolipin antibodies (aCL), IgG phospholipid-dependent anti-beta 2-glycoprotein I (beta 2-GPI) antibodies and IgG anti-Annexin V antibodies were identified as serological features in SLE patients with thrombosis. These patients were diagnosed as having antiphospholipid syndrome. It was necessary to perform primary prevention therapy as well as secondary prevention therapy. Multiple thrombotic events in the past history and sustained positive reactions of IgG aCL were suggested as predictors of recurrent thrombosis. These data indicated the clinical and serological characteristics in SLE patients with arterial or venous thrombosis.
对患有动脉或静脉血栓形成的系统性红斑狼疮（SLE）患者的临床和血清学特征进行了研究。研究对象包括140例符合美国风湿病学会修订的SLE分类标准的SLE患者。40例患者（29%）发生了动脉或静脉血栓形成。30例患者出现动脉血栓形成，如中风；24例患者出现静脉血栓形成，如深静脉血栓形成。疾病发病的平均年龄为34.5±12.5岁。肾脏疾病被发现为临床特征，IgG抗心磷脂抗体（aCL）、IgG磷脂依赖性抗β2糖蛋白I（β2-GPI）抗体和IgG抗膜联蛋白V抗体被确定为血栓形成的SLE患者的血清学特征。这些患者被诊断为抗磷脂综合征。进行一级预防治疗以及二级预防治疗是必要的。既往有多次血栓形成事件和IgG aCL持续阳性反应被认为是复发性血栓形成的预测因素。这些数据表明了患有动脉或静脉血栓形成的SLE患者的临床和血清学特征。
