Takekawa Y, Sawada T, Sakurai I
2nd Department of Pathology, Nihon University School of Medicine, Tokyo.
Rinsho Byori. 1995 May;43(5):483-6.
A new grading method of astrocytoma, proposed by Daumas-Duport et al, was based on four criteria:nuclear atypia, mitosis, necrosis and endothelial proliferation (0 criteria = Grade 1, 1 criteria = Grade 2, 2 criteria = Grade 3, 3 or 4 criteria = Grade 4). To elucidate the correlation of the classification based on four criteria, cellularity and proliferative activities, we studied proliferating index of 67 astrocytomas, using immunohistochemical staining for Ki-67 antibodies (MIB-1). A new grading method was related to proliferating index in this study, however, cellularity of tumor cells was not related to proliferating index. In this study, endothelial proliferation was invariably seen in high grade(Grade 3 and 4) astrocytomas. These tumor vessels were associated with dysfunction of blood-brain barrier and some growth factors accelerated to tumor cell proliferation. Relation between histopathological grade of astrocytoma and proliferation index was supposed, and new grading system was thought to be useful for routine pathological examination.
Daumas-Duport等人提出的一种新的星形细胞瘤分级方法基于四个标准：核异型性、有丝分裂、坏死和内皮细胞增殖（0个标准 = 1级，1个标准 = 2级，2个标准 = 3级，3个或4个标准 = 4级）。为了阐明基于四个标准的分类与细胞密度和增殖活性之间的相关性，我们使用Ki-67抗体（MIB-1）免疫组化染色研究了67例星形细胞瘤的增殖指数。在本研究中，新的分级方法与增殖指数相关，然而，肿瘤细胞的细胞密度与增殖指数无关。在本研究中，高级别（3级和4级）星形细胞瘤中总是可见内皮细胞增殖。这些肿瘤血管与血脑屏障功能障碍有关，一些生长因子加速了肿瘤细胞的增殖。推测了星形细胞瘤组织病理学分级与增殖指数之间的关系，认为新的分级系统对常规病理检查有用。
