Matsuda M, Aono M, Moriga M, Okuma M
Department of Gastroenterology, Shizuoka General Hospital.
Nihon Shokakibyo Gakkai Zasshi. 1995 May;92(5):855-61.
We investigated the central effects of neuropeptide Y (NPY) on stress-induced gastric ulcers in water immersion rats. Intracisternally administered NPY dose-dependently aggravated, but intravenously administered NPY did not affect stress ulcers in rats. Intraperitoneal pre-treatment of atropine completely blocked the central effect of NPY, but neither pyrilamine nor cimetidine affected. Intracisternal administration of NPY aggravated stress ulcers not through histamine mediated mechanism but by parasympathetic pathway. It is suggested that centrally administered NPY acted by the inhibition on gastric motility and by the suppression on gastric mucosal blood flow rather than by the stimulation on gastric secretion in rats.
我们研究了神经肽Y（NPY）对水浸应激大鼠胃溃疡的中枢作用。脑池内注射NPY可剂量依赖性地加重大鼠应激性溃疡，但静脉注射NPY对其无影响。腹腔注射阿托品预处理可完全阻断NPY的中枢作用，但吡苄明和西咪替丁均无此作用。脑池内注射NPY加重应激性溃疡并非通过组胺介导机制，而是通过副交感神经途径。提示脑内注射NPY在大鼠中起作用的机制是抑制胃动力和抑制胃黏膜血流，而非刺激胃分泌。
