Schmidt R T, Lee R H, Spehlmann R
J Neurol Neurosurg Psychiatry. 1976 Apr;39(4):350-6. doi: 10.1136/jnnp.39.4.350.
The effects of dantrolene sodium and diazepam were compared in a double crossover study of 42 patients with spasticity due to stable multiple sclerosis. Both drugs reduced the findings of spasticity, clonus, and hyperreflexia, and the complaints of muscle stiffness and cramping. Each drug had different side effects which suggest indications and contraindications for its use in spastic patients.
在一项针对42例因稳定型多发性硬化症导致痉挛的患者的双交叉研究中,比较了丹曲林钠和地西泮的效果。两种药物均减轻了痉挛、阵挛和反射亢进的表现,以及肌肉僵硬和抽筋的主诉。每种药物都有不同的副作用,这提示了其在痉挛患者中使用的适应证和禁忌证。