Konecny J, Schöniger M, Hofacker G L
Tech University of Munich, Germany.
J Theor Biol. 1995 Apr 7;173(3):263-70. doi: 10.1006/jtbi.1995.0061.
The hypothesis that the universal genetic code is adapted to double-strand coding is supported by its remarkable compatibility with the RNY comma-less hypothesis. Coding by a triplet code on a polynucleotide double-strand allows for enciphering of five additional messages with reference to a chosen primary reading frame. Assuming the acceptance of coupled mutations on both strands, the best codon register for two overlapping messages can be inferred. The idea of evolutionarily compatible coding of two proteins by one nucleotide double-strand is extended to complementary coding for one protein in folded, single-stranded RNA.
通用遗传密码适应双链编码这一假说，得到了它与RNY无逗号假说显著兼容性的支持。在多核苷酸双链上通过三联体密码进行编码，相对于选定的主要阅读框而言，能够加密五条额外信息。假设两条链上都接受耦合突变，就可以推断出两条重叠信息的最佳密码子排列。由一个核苷酸双链对两种蛋白质进行进化上兼容编码的想法，被扩展到在折叠的单链RNA中对一种蛋白质进行互补编码。
