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[颅咽管瘤的根治性手术还是保守性手术?个体化治疗的重要性!]

[Radical or conservative surgery in craniopharyngioma? Importance of individualized treatment!].

作者信息

Lannering B, Westgren U

机构信息

Barnoch ungdomsmedicinska kliniken, Ostra sjukhuset, Göteborg.

出版信息

Lakartidningen. 1995 May 31;92(22):2301-5.

PMID:7783489
Abstract

In a retrospective study of 36 children aged 3-16 years, undergoing 'radical' surgery for craniopharyngioma, postoperative radiography showed tumour excision to have been complete in 25 cases and partial in 11 cases. The recurrence rate was 40% among those treated with surgery alone (N = 27), whereas there were no recurrences among those given adjunctive radiotherapy (RT) (N = 9). Although surgery in the hypothalamic region carries a high risk of severe lasting sequelae, long-term follow-up (mean duration 15 years) showed no difference in this respect between the RT and non-RT subgroups. Until large, preferably international, prospective studies may resolve the lack of consensus regarding the optimal treatment of craniopharyngioma, the authors advocate a more individualised approach, the choice between different treatment modalities and combinations being based on tumour size, location and structure.

摘要

在一项针对36名年龄在3至16岁、接受颅咽管瘤“根治性”手术的儿童的回顾性研究中,术后影像学检查显示,25例肿瘤切除完全,11例部分切除。单纯接受手术治疗的患者(N = 27)复发率为40%,而接受辅助放疗(RT)的患者(N = 9)无复发。尽管下丘脑区域手术有严重持久后遗症的高风险,但长期随访(平均时长15年)显示,放疗组与非放疗组在这方面并无差异。在大型、最好是国际性的前瞻性研究解决关于颅咽管瘤最佳治疗方法缺乏共识的问题之前,作者主张采用更个体化的方法,不同治疗方式及其组合的选择应基于肿瘤大小、位置和结构。

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