Westermark B
Institutionen för patologi, Akademiska sjukhuset, Uppsala.
Lakartidningen. 1995 Jun 7;92(23):2397-401.
Platelet-derived growth factor (PDGF) is a 30 kilodalton dimeric peptide comprising A and B chains. The two types of PDGF receptors (alpha and beta) that have been identified belong to the protein-tyrosine kinase family of growth factor receptors. PDGF is a potent mitogen for a variety of cell types, and in gene knock-out experiments has been shown to be required for the development of inter alia mesangial cells of renal glomeruli and smooth muscle cells of lung alveolar septa. PDGF is believed to fulfil important autocrine and paracrine growth-related functions, and its overproduction has been recognised in various malignant tumours and in non-neoplastic hyperproliferative disorders.
血小板衍生生长因子（PDGF）是一种由A链和B链组成的30千道尔顿的二聚体肽。已鉴定出的两种类型的PDGF受体（α和β）属于生长因子受体的蛋白酪氨酸激酶家族。PDGF是多种细胞类型的强效有丝分裂原，在基因敲除实验中已表明，它对于肾小肾小球系膜细胞和肺泡隔平滑肌细胞等的发育是必需的。PDGF被认为具有重要的自分泌和旁分泌生长相关功能，并且其过量产生已在各种恶性肿瘤和非肿瘤性增殖性疾病中得到确认。
