Richard P, Amador Del Valle G, Moreau P, Milpied N, Felice M P, Daeschler T, Harousseau J L, Richet H
Laboratoire de Bactériologie A, Hôtel-Dieu, Nantes, France.
Lancet. 1995 Jun 24;345(8965):1607-9. doi: 10.1016/s0140-6736(95)90117-5.
Viridans streptococcal bacteraemia is frequent in neutropenic patients. 25 neutropenic patients with viridans streptococcal bacteraemia were compared with 64 control patients. Exposure to repeated chemotherapy or cytarabine were independent risk-factors for streptococcal bacteraemia. The use of carboxyureidopenicillins and a stay in laminar-airflow rooms were protective. In a further cohort study of 49 patients, oral streptococci with the same ribotype as blood isolates were recovered from all 7 bacteraemic patients. The oral cavity is a portal of entry for viridans streptococci bacteraemia in neutropenic patients, especially after oral mucosal damage induced by repeated chemotherapy.
草绿色链球菌菌血症在中性粒细胞减少患者中很常见。将25例患有草绿色链球菌菌血症的中性粒细胞减少患者与64例对照患者进行了比较。反复化疗或使用阿糖胞苷是链球菌菌血症的独立危险因素。使用羧脲基青霉素和住在层流室有保护作用。在另一项对49例患者的队列研究中，从所有7例菌血症患者中均分离出与血液分离株具有相同核糖型的口腔链球菌。口腔是中性粒细胞减少患者草绿色链球菌菌血症的入口，尤其是在反复化疗引起口腔黏膜损伤之后。
