Ling L, Bach K B, Mitchell G S
Department of Comparative Biosciences, University of Wisconsin, Madison 53706, USA.
Neurosci Lett. 1995 Mar 16;188(1):25-8. doi: 10.1016/0304-3940(95)95690-d.
Serotonin reveals ineffective spinal pathways from the C2-lateral funiculus to contralateral phrenic motoneurons in young adult rats with acute spinal hemisection. We tested the hypothesis that old age (1.5-2 years) or chronic hemisection (3-5 days) strengthens these pre-existing crossed spinal pathways. There were no consistent differences between young adult rats with acute hemisection versus young adult rats with chronic hemisection or old rat with acute hemisection except that one long-latency phrenic excitation could not be elicited in old rats. The results indicate that neither old age nor chronic hemisection strengthens crossed-spinal pathways, but that old age may selectively diminish spinal pathways involved in the neural control of breathing.
血清素显示，在急性脊髓半横断的年轻成年大鼠中，从C2侧索到对侧膈运动神经元的脊髓通路无效。我们测试了这样一个假设，即老年（1.5 - 2岁）或慢性半横断（3 - 5天）会加强这些预先存在的交叉脊髓通路。急性半横断的年轻成年大鼠与慢性半横断的年轻成年大鼠或急性半横断的老年大鼠之间没有一致的差异，只是老年大鼠中无法诱发一种长潜伏期的膈神经兴奋。结果表明，老年和慢性半横断都不会加强交叉脊髓通路，但老年可能会选择性地减少参与呼吸神经控制的脊髓通路。
