Madani A, Soulier J, Schmid M, Plichtova R, Lermé F, Gateau-Roesch O, Garnier J P, Pla M, Sigaux F, Stern M H
Laboratoire d'Hématologie Moléculaire, Hôpital Saint Louis, Paris, France.
Oncogene. 1995 Jun 1;10(11):2259-62.
An unusually small (8 kD) protein (p8MTCP-1) is coded by the putative oncogene MTCP-1 (also called c6.1B), involved in the translocation t(X;14)(q28;q11) associated with some mature T-cell proliferations. Here, we show by subcellular fractionation and by confocal microscopy that this protein is located in the mitochondria. This localization orientates toward a role of p8MTCP-1 in the mitochondrial metabolism which may be relevant for the oncogenic process.
一种异常小（8千道尔顿）的蛋白质（p8MTCP-1）由假定的致癌基因MTCP-1（也称为c6.1B）编码，该基因参与了与某些成熟T细胞增殖相关的t(X;14)(q28;q11)易位。在此，我们通过亚细胞分级分离和共聚焦显微镜显示，这种蛋白质定位于线粒体。这种定位表明p8MTCP-1在线粒体代谢中发挥作用，这可能与致癌过程相关。
