[125I]SNF 8702：一种用于CCKB受体的选择性放射性配体。
[125I]SNF 8702: a selective radioligand for CCKB receptors.
作者信息
Slaninova J, Knapp R J, Weber S J, Davis T P, Fang S N, Hruby V J, Yamamura H I
机构信息
University of Arizona College of Medicine, Department of Pharmacology, Tucson 85724, USA.
出版信息
Peptides. 1995;16(2):221-4. doi: 10.1016/0196-9781(94)00168-5.
The CCK-8 analogue, SNF 8702, was radioiodinated. [125I]SNF 8702 showed high-affinity specific binding for both guinea pig and mouse brain tissues, whereas no specific binding was seen for guinea pig pancreatic tissue. The properties of the site labeled by [125I]SNF 8702 were characterized by binding inhibition studies for a series of CCKA and CCKB receptor ligands. The binding selectivity profile corresponded to that for the CCKB receptor. The labeled compound is stable for more than 6 weeks during storage at -20 degrees C.
胆囊收缩素-8类似物SNF 8702进行了放射性碘化。[125I]SNF 8702对豚鼠和小鼠脑组织均显示出高亲和力特异性结合，而豚鼠胰腺组织未见特异性结合。通过对一系列CCKA和CCKB受体配体的结合抑制研究，对[125I]SNF 8702标记位点的特性进行了表征。结合选择性图谱与CCKB受体的图谱一致。标记化合物在-20℃储存期间6周以上保持稳定。
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